Bridging causal biology and breakthrough protein engineering.
Targeting causal biology...
Overactive Activin and GDF signaling has been established as a causal driver of pulmonary hypertension, heart failure and obesity by genetic, translational and clinical evidence.
Multiple Activin and GDF ligands act in a redundant and compensatory fashion to drive these diseases.
Simultaneous blocking of multiple Activin and GDF ligands is required for optimal therapeutic effect due to the redundant and compensatory nature of these growth factors.
...with next-generation ligand traps.
Ligand traps, due to their inherent multi-specificity, hold the unique power to precisely and effectively target Activin and GDF biology.
Using a novel combinatorial protein engineering approach, integrating precision mutagenesis with diverse spatial presentations of ligand-binding domains, we have expanded the protein design space and overcome limitations in selectivity and potency of earlier-generation traps.
This allows us to purposefully engineer next-generation Activin x GDF ligand traps with tailored neutralization profiles and class-leading therapeutic indices.
Development
Targeting high probability of success indications
supported by strong evidence of Activins and GDFs as causal drivers to maximize clinical success.
Biomarker-informed, efficient development plans
that aim to deliver rapid Proof-of-Principle for the potential benefit of our drug candidates in patients.
Powered by decades of experience, enhanced by structure-based AI-assisted rational design
Our team leverages deep expertise in complex biologics design, development, and manufacturing, combined with advanced computational and experimental methods.
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35Pharma is a biopharmaceutical company focused on designing and developing innovative biologics for diseases with high unmet medical need.