HS235 is a multi-specific Activin x GDF decoy trap that was engineered for exceptional selectivity, potency, and extended half-life. HS235 potently blocks pathological Activins and GDFs. Uniquely, HS235 is highly sparing of both BMP-9 and BMP-10 which are critical ligands for maintaining the integrity of blood vessels and the lymphatic system. This unique neutralization profile is expected to result in excellent efficacy, safety and tolerability.
By virtue of potent and selective targeting of Activins and GDFs, HS235 has the potential to improve pulmonary and cardiac function as well as achieve increased fat-loss without compromising skeletal muscle. We believe that HS235’s proposed dual cardio-pulmonary and body composition mode of action may benefit large patient populations suffering from pulmonary hypertension, heart failure and obesity.