35Pharma Announces Oral Presentation of HS235 Pre-Clinical Data in Obese HFpEF at Obesity Week 2024.

35Pharma, a clinical-stage biopharmaceutical company that designs and develops TGF-beta superfamily therapeutics, today announced that it has been selected for an oral presentation at ObesityWeek® 2024 in San Antonio, TX, USA (Nov 3-6, 2024).

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HS235 is an Fc-fused ligand trap that selectively and potently neutralizes pathological Activins and growth differentiation factors (GDFs). The Company has recently been cleared to commence Phase 1 clinical testing of HS235 in overweight and obese healthy subjects, and anticipates sharing initial data from this trial during the second half of 2025.

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During an oral presentation at Obesity Week 2024, 35Pharma Chief Scientific Officer Maureen O’Connor will share pre-clinical data with HS235 demonstrating its dual metabolic and cardiac activity in a murine model of obese Heart Failure with preserved Ejection Fraction (HFpEF).

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In this heart failure model, HS235 treatment positively impacted both cardiac function and metabolic health. Specifically, HS235 administration resulted in:

• decrease in fat mass, including pericardial fat
• increase in muscle mass
• rescue of left ventricular function
• reduction of circulating NT-proBNP, a biomarker of heart failure
• return of exercise capacity to the levels of lean control